CytoHub receives the Impact Award at The AI Summit @ Stanford
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CytoHub.AI

AI that learns from living human tissue.

Every customer run of real human heart tissue adds to what CytoHub.AI learns.

  • 3 AI tools live
  • 4 AI patent families
  • Next CytoRNA-FM
CytoHub.AI core: imaging, electrophysiology, contractility, single-cell RNA and bioprocess data flow into one model CytoHub.AI ● SI CORE ImagingElectrophysiologyContractilitySingle-cell RNABioprocess

The feedback loop

Many readouts. One picture of the cell.

Readouts from the same tissue show how structure, function and genes move together. CytoHub.AI learns those links.

The CytoHub data wheel: assays in, decisions out Six readouts from the same CardioVive tissue (imaging, electrophysiology, contractility, single-cell RNA and qPCR, flow cytometry and bioprocess) flow into CytoHub.AI. It supports drug safety, discovery, QA/QC batch release, potency assays and therapeutic development. Results design the next experiment. 01 Measure 02 Learn 03 Decide ImagingImmunofluorescence · live-cell LIVE ElectrophysiologyVoltage imaging · MEA · APD LIVE ContractilityMotion vectors · beat rate · force LIVE Single-cell RNACell types · expression · qPCR BUILDING Flow cytometryCell identity · purity LIVE Bioprocess0.1–15 L bioreactor · analytics LIVE DRUG SAFETYCardiotoxicity · arrhythmia DISCOVERYDisease signatures · targets QA / QCIdentity · purity · release POTENCY ASSAYSFunctional potency per lot THERAPEUTIC DEVELOPMENTHeartReady™ · efficacy CytoHub.AI● SI CORE One map of human cell biology 04 TESTResults design the next CardioVive experimentBUILDING The CytoHub data wheel: assays in, CytoHub.AI, decisions out, and back 01 Measure ImagingImmunofluorescence · live-cell LIVE ElectrophysiologyVoltage imaging · MEA · APD LIVE ContractilityMotion vectors · beat rate · force LIVE Single-cell RNACell types · expression · qPCR BUILDING Flow cytometryCell identity · purity LIVE Bioprocess0.1–15 L bioreactor · analytics LIVE 02 Learn · CytoHub.AI CytoHub.AI● SI CORE 03 Decide DRUG SAFETYCardiotoxicity · arrhythmia DISCOVERYDisease signatures · targets QA / QCIdentity · purity · release POTENCY ASSAYSFunctional potency per lot THERAPEUTIC DEVELOPMENTHeartReady™ · efficacy 04 TESTDesigns the next experiment
Illustrative. Imaging, electrophysiology, contractility, flow and bioprocess readouts run today; in-house sequencing, prediction and the closed loop are being built.
  1. Measure Live

    Up to five readouts from the same living human tissue, linked to compound, dose and batch.

  2. Learn Live

    CytoHub.AI places every cell on one map of human cell biology.

  3. Predict Building

    Cell states, disease signatures and drug response, before the next experiment runs.

  4. Test Building

    Predictions choose the next CardioVive experiment. Its results correct the model.

Live today

Three tools, already in use.

Live

CytoMOTION

Contraction kinetics measured from video of beating tissue: rate, force and relaxation.

Live

CytoVISION

Image-based phenotyping that scores structure and cell composition across every well.

Live

CytoGPT

Answers questions across your study data and the scientific literature, with sources.

CytoRNA-FM · foundation model · building

A heart model on a proven foundation.

CytoRNA-FM builds on scVision, a single-cell foundation model from our Stanford collaborators, and is being tuned on CardioVive heart data that no public atlas contains.

  1. Cells as imagesEach cell is painted on a fixed map of 10,816 genes.
  2. Learned without labelsAbout 86M parameters, pre-trained on 72M public human cells.
  3. Disease that transfersA cardiomyopathy signature carried across disease subtypes.

Read the scVision preprint

scVision results in the preprint

6held-out studies led vs other foundation models
>50×fewer labels needed
−44%accuracy if the gene map is scrambled

Zero-shot, frozen encoder, public data. Heart-specific results follow fine-tuning.

Roadmap

From tools to a digital twin.

  1. LiveAI tools

    CytoMOTION, CytoVISION and CytoGPT in use on partner studies.

  2. NextHeart-tuned CytoRNA-FM

    The foundation model fine-tuned on CardioVive single-cell data.

  3. In developmentSafety digital twin

    Simulate how human heart tissue responds to a compound before it is dosed.

Put human cell data to work on your next decision.

Pilot studies, data partnerships, investor meetings and Cardia Therapeutics partnerships.